Higher doses have a greater effect, but the decrease in cardiovascular disease outweighs the risk of developing diabetes. Statin use is linked to an increased risk of type 2 diabetes among highrisk individuals, a new study reports. Scientists found that people with naturally lower levels of lowdensity lipoprotein ldl. In the presence of diabetes, statin use was statistically significantly associated. Nonfasting lipid panel is now the preferred cholesterol test. It is unknown whether statins similarly modify diabetes risk in higher.
Risk enhancers that are independent of other risk factors in diabetes. In this issue of the archives, culver et al report an association between use of statins and increased risk of developing diabetes mellitus in a large cohort of women enrolled in the womens health initiative. Statin use and risk of diabetes mellitus in postmenopausal. Medical management of type 2 diabetes, 7th edition. Dec 11, 2014 in 2010, a clinical trial metaanalysis reported that statin therapy overall was associated with a slightly increased risk of new onset diabetes nod. The link between statin use and the development of type 2 diabetes. Now, further research is beginning to uncover the specific circumstances under which statin use is likely to raise a persons risk of developing the condition. In particular, recent overviews show that all statin agents are associated with a small increase in risk of incident type 2 diabetes hazard ratio hr 109, 95% ci 102117, 3 and that intensive. The combination of statin treatment and increased fitness resulted in substantially lower mortality risk than either alone, reinforcing the importance of physical activity for individuals with dyslipidaemia. If there is too much cholesterol in the blood, some of the excess can become trapped in artery walls. American diabetes association indications for statins in. Pdf statin utilization patterns among type 2 diabetes mellitus. Participants 46 864 people aged 75 years or more without clinically recognised. Objective several clinical trials of cardiovascular disease prevention with statins have reported increased risk of type 2 diabetes t2dm with statin therapy.
You are advised to consult the publishers version publishers pdf. Annual ldl monitoring is no longer required for people on a statin or with diabetes. Mar 04, 2015 use of statins is associated with a 46 percent increase in the risk of developing diabetes, even after adjustment for confounding factors, a new study concludes. Statins are cholesterollowering drugs that are frequently used as part of diabetes care due to the knowledge that people with diabetes face a greater likelihood of heart attack and stroke. Simvastatin was the preferred statin for primary prevention. In patients with diabetes mellitus at higher risk, especially those with multiple risk factors or those 50 to 75 years of age, it is reasonable to use a highintensity statin to reduce the ldlc level by. Researchers found that statins were associated with an almost 50 percent higher risk of developing type 2 diabetes, even after adjusting for other factors. There is strong evidence of reductions in major vascular events from statins across all cardiovascular risk categories.
Use of statin therapy in patients with type 2 diabetes mellitus has been recommended by most clinical guidelines. In ontario drug benefit database patients treated with atorvastatin were found to have a 22% increased risk of newonset diabetes, rosuvastatin an 18% increased risk and simvastatin a 10% increased risk. The diabetes risk increased with the dosage taken of the statin drugs simvastatin and atorvastatin, the researchers said. Statin use is linked to an increased risk of type 2 diabetes among high risk individuals, a new study reports. We conducted a metaanalysis of published observational studies to evaluate the association between statins use and risk of nod. The guidelines recommend moderate to highintensity statin therapy for patients ages 4075 with diabetes to help prevent atherosclerotic cardiovascular disease ascvd. Use of statins increases risk of developing diabetes by 46. Lowering the bad form of cholesterol with statin drugs could increase diabetes risk, a study suggests.
Statins linked to increased risk of type 2 diabetes. Statin therapy effectively reduces cardiovascular events. Statin treatment and increased fitness are independently associated with low mortality among dyslipidaemic individuals. Cholesterol management guide american heart association.
For patients with cardiovascular disease or a history of heart attack, the benefits of taking a statin drug often outweigh the risk of. These data confirm and extend associations previously demonstrated among participants in randomized trials. Dear editor, the findings about statin use and associated risk of type 2 diabetes in postmenopausal women are certainly meritorious of attention and further studies. Digging a little deeper, the investigators found that statins decreased insulin sensitivity by 24 percent, and insulin secretion by 12 percent. Statins linked to raised risk of type 2 diabetes medicinenet.
Use a maximally tolerated statin to lower ldlc levels by. One is that the drugs can increase a persons insulin resistance, and the other is that the. Statins and the potential for higher diabetes mellitus risk taylor. Diabetes and statins have a complex relationship and are the focus of intense patient and healthcare debate. Pdf increased risk of diabetes with statin treatment is associated. Earlier this year, we reported on a study showing an increased risk of developing type 2 diabetes associated with using the cholesterollowering medicines known as statins. This risk was not materially altered by adjustment for baseline diabetes risk factors and potential confounders related to indications for statin therapy. Decreases in insulin sensitivity and insulin secretion were dose dependent for simvastatin and atorvastatin. Statins appear to increase the risk of type 2 diabetes in several ways, the researchers said.
Conclusions in participants older than 74 years without type 2 diabetes, statin treatment was not associated with a reduction in atherosclerotic cvd or in all cause mortality, even when the incidence of atherosclerotic cvd was statistically significantly higher than the risk thresholds proposed for statin use. Longterm statin use is associated with an increased risk of type 2 diabetes of approximately 30% in individuals at high risk of the disease. Statin therapy appears to increase the risk for type 2 diabetes by 46%, even after adjustment for confounding factors, a large new populationbased study concludes. It is unknown whether statins similarly modify diabetes risk in higher risk. While some but not all trial data have suggested an elevated risk of type 2 diabetes with statin use, limited data are available on the relation of statin treatment with glycaemia and risk. However, participants in these studies were at relatively low risk for diabetes. However, i would like to raise a concern about the interpretation of the data. However, trials of statin therapy have provided conflicting results regarding statin use and type 2 diabetes t2dm. In february 2012, food and drug administration released changes to statin safety label to include that statins have been found to increase haemoglobin hba1c and fasting serum glucose levels. Further, diabetes was often based on selfreport and was not the primary outcome.
There are other medicines that improve cholesterol. Jan 23, 2012 dear editor, the findings about statin use and associated risk of type 2 diabetes in postmenopausal women are certainly meritorious of attention and further studies. Use in postmenopausal women is associated with an increased risk for diabetes. Taking a statin to reduce the risk of coronary heart disease. Although observational data are potentially susceptible to bias by indication. Experts sound new alarm over cholesterol pill pensioners who take statins increase their risk of developing diabetes by up to 50 per cent, research shows. An analysis of participants from jupiter trial to address the balance of vascular benefits versus diabetes risk of statin use. In 2010, a clinical trial metaanalysis reported that statin therapy overall was associated with a slightly increased risk of new onset diabetes nod. The scientific statement from the american heart association presents evidence for a minimal risk 0. Annual ldl monitoring was recommended for all patients on a statin. In adults 40 to 75 years of age evaluated for primary ascvd prevention, have a clinicianpatient. Largest risk for diabetes with statins yet seen, in new study. Statin associated diabetes increasing heart disease risk. Wednesday, march 4, 2015 healthday news cholesterollowering statin drugs may significantly increase a persons risk of developing type 2 diabetes, a new study from finland suggests.
There is a link between type 2 diabetes and statin use. Patients concerned about the increased risk of diabetes with statins should have the risk put in context. This release has brought in the debate of using statins in patients with cardiovascular risk factors like diabetes. The pharmacy quality alliance endorsed a performance measure, statin use in persons with diabetes, which evaluates the percentage of patients aged 4075 years who were dispensed a medication for diabetes and also received a statin medication. Statin use raises diabetes risk even in highrisk patients. Mancia g, bombelli m, facchetti r, madotto f, quartitrevano. Setting database of the catalan primary care system sidiap, spain, 200615.
This decision aid is intended to help you to make up your mind whether or not to take a statin to help reduce your risk of having a heart attack or developing angina together called coronary heart disease or chd, or of having a stroke. Risk of newonset diabetes among patients treated with statins. The more ldlc is reduced on statin therapy, the greater will be subsequent risk reduction. Longterm statin use is associated with an increased risk of type 2 diabetes of approximately 30% in individuals at high risk of the disease, even after taking into account known risk factors and. Cardiovascular benefits and diabetes risks of statin.
Ask your doctor about whether you should take a statin or other drug to lower your risk for heart attack or stroke. Ascvd primary prevention guideline kaiser permanente. We carried out a populationbased cohort study using the clinical practice research. A low level of hdl cholesterol increases your risk for heart disease. Moreover, statin treatment might cause organ damage and increase the risk of several diseases. Cholesterol medications most adults with diabetes who are 40 years or older should be taking a statin. Objective to assess whether statin treatment is associated with a reduction in atherosclerotic cardiovascular disease cvd and mortality in old and very old adults with and without diabetes. Objective several clinical trials of cardiovascular disease prevention with statins have reported increased risk of type 2 diabetes t2dm with. University of groningen statin treatment in type 2 diabetes. Should all diabetic patients take statin therapy regardless of serum. Statins linked to raised risk of type 2 diabetes webmd. It is important to understand the balance between the risks and benefits of statin prescription in various atrisk groups to facil itate safe and. We aimed to assess the effect of statins on t2dm development.
Individualize all glycemic targets a1c, fpg, ppg 5. Statin use linked to heightened type 2 diabetes risk in. Statins are cholesterollowering drugs prescribed to reduce cardiovascular risks, but a variety of studies have shown the drugs have an association with type 2 diabetes development. We urge you to consider adding the clinically appropriate intensity of statin therapy to optimize. During the past 2 decades, numerous randomized controlled studies have proven that for every 1 mmoll reduction in ldlc achieved by use of statin drugs, the relative risk of a cardiovascular. Diabetes and statins what are statins, effect on cholesterol. Aug 03, 2016 lowering the bad form of cholesterol with statin drugs could increase diabetes risk, a study suggests. Pdf statin induced diabetes and its clinical implications. Statin intolerance is the inability to tolerate a dose of statin required to reduce a persons cv risk sufficiently from their baseline risk and could result from different statin related side effects including. The american diabetes association ada standards of care for diabetes state that statin therapy should be initiated in individuals with diabetes and other cardiovascular risk factors with a target ldl cholesterol of diabetes and cardiovascular disease. Statin use linked to increased risk of type 2 diabetes diabetes. Statin use indicates that the subjects had high cholesterol levels andor high lipid levels.
Interactive effects of fitness and statin treatment on. Statin treatment increased the risk of type 2 diabetes. Use of statins is associated with a 46 percent increase in the risk of developing diabetes, even after adjustment for confounding factors, a new study concludes. Analyses of diabetes mellitus risks were also performed in a separate propensity.
Statin use linked to increased risk of type 2 diabetes. The effect of statins to increase diabetes risk appears to extend to populations at high risk for diabetes. Taking a statin to reduce the risk of coronary heart. Statins increase the risk of diabetes by about 11%, while hypertension and obesity increase diabetes risk by approximately 100% and 200%, respectively. Mar 15, 2015 while analysing one of the initial studies which suggested the link between statins and diabetes, it was found that rate of reduction of cardiovascular events outbalanced the risk of incident diabetes even in patients at highest risk for diabetes though the absolute risk increase was small placebo 1. Jul 15, 2014 furthermore, it appears that the risk of statin induced diabetes is higher with intensivedose statin therapy and among elderly people 6, 16. Statins may increase risk of diabetes the new york times. Statins help lower ldl levels and reduce your risk for heart attack or stroke. Risk factors impact diabetesstatin link diabetes self. Longterm statin use is associated with an increased risk of type 2 diabetes of approximately 30% in individuals at highrisk of the disease, even after taking into account known risk factors and potential confounders, say us researchers they looked at the development of diabetes among statin users in the diabetes prevention program dpp, which included more. Results at 10 years, the cumulative incidence of statin initiation prior to diabetes diagnosis was 33%37% among the randomized treatment groups p0.
Yet, trial data 1 and metaanalyses2, 3, 4 suggest that statins also confer increased risk of development of diabetes. Hypertension goals for most people with diabetes and hypertension a. Mar 04, 2015 statins appear to increase the risk of type 2 diabetes in several ways, the researchers said. Pharmacisttoprescriber intervention to close therapeutic. Statins are drugs used to reduce the levels of cholesterol in the blood, with the aim of reducing the risk of cardiovascular events such as heart attacks. These new findings were from a longterm us study of. In patients with clinical ascvd, reduce lowdensity lipoprotein cholesterol ldlc with highintensity statin therapy or maximally tolerated statin therapy. Diabetes itself confers independent risk daly a, power ma. Recognize patients ages 4075 with diabetes are at a substantially higher lifetime risk for ascvd events and. Statin use was associated with greater diabetes risk irrespective of treatment group, with pooled hr 95% ci for incident diabetes of 1. Jan 23, 2012 in this issue of the archives, culver et al report an association between use of statins and increased risk of developing diabetes mellitus in a large cohort of women enrolled in the womens health initiative.
148 487 258 1088 1104 1340 785 1442 40 298 1162 1438 210 179 1168 1196 198 1182 59 122 823 765 1533 1317 444 1479 1464 1074 1031 229 290 750 802 561 1308 79 6 31 1204 1447 1105